This Month In Muscular Dystrophy

Guest: Jill Rafael-Fortney, PhD, Department of Molecular and Cellular Biochemistry, The Ohio State University Access an abstract of this month’s featured research article: Early Treatment with Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice. Circulation. 2011 Aug 2;124(5):582-8.

Guest: Valérie Allamand, PhD, the Institute of Myology, Paris, France Access an abstract of this month’s featured research article: Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency. Hum Mol Genet. 2011 Feb 15;20(4):694-704.

Guest: Dr. Carsten Bonnemann, MD, Senior Investigator, Neurogenetics Branch, and Chief of Neuromuscular and Neurogenetic Disorders of Childhood Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health Access an abstract of this month's featured research article: Large genomic deletions: a novel cause of Ullrich congenital muscular dystrophy. Ann Neurol. 2011 Jan;69(1):206-11.

Guest: Paul Martin, PhD, principal investigator, Center for Gene Therapy, The Research Institute at Nationwide Children’s Hospital Access an abstract of this month’s featured research article: A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Sci Transl Med. 2010 Jul 28;2(42):42ra54.

Guest: Scott Harper, PhD, Nationwide Children's Hospital Access an abstract of this Month's Featured Research Article: DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo. Ann Neurol. 2010 Oct 28. [Epub ahead of print]

Guest: Jerry Mendell, MD, Nationwide Children's Hospital Access an abstract of this Month's Featured Research Article: Dystrophin immunity in Duchenne's muscular dystrophy. N Engl J Med. 2010 Oct 7;363(15):1429-37.

Guest: Dr. Craig McDonald, Chair and Professor of Physical Medicine and Rehabilitation and Professor of Pediatrics at UC Davis Access full-text versions of this Month's Featured Research Articles: The 6-minute walk test in Duchenne/Becker muscular dystrophy: longitudinal observations. Muscle Nerve. 2010 Dec;42(6):966-74. The 6-minute walk test as a new outcome measure in Duchenne muscular dystrophy. Muscle Nerve. 2010 Apr;41(4):500-10.

Guest: Dr. Annemieke Aartsma-Rus, DMD Genetic Therapy Group, Dept. of Human Genetics, Leiden University Medical Center, The Netherlands Access an abstract of this Month's Featured Research Article: Progress in therapeutic antisense applications for neuromuscular disorders. Eur J Hum Genet. 2010 Feb;18(2):146-53.

Guest: Federica Montanaro, PhD, Nationwide Children's Hospital Access an abstract of this Month's Featured Research Article: Analysis of dystrophin deletion mutations predicts age of cardiomyopathy onset in becker muscular dystrophy. Circ Cardiovasc Genet. 2009 Dec;2(6):544-51.

Guest: Professor Kate Bushby, joint coordinator of the TREAT-NMD network Access full-text versions of this Month's Featured Research Articles: The diagnosis and management of Duchenne muscular dystrophy Part 1: diagnosis, and pharmacological and psychosocial management; Part 2: implementation of multidisciplinary care View the Supplemental Family Guide: DMD guide for families

Guest: Brian Kaspar, PhD, Nationwide Children's Hospital Access an abstract of this Month's Featured Research Article: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN. Nat Biotechnol. 2010 Mar;28(3):271-4.

Guest: Jerry Mendell, MD, Nationwide Children's Hospital Access an abstract of this Month's Featured Research Article: Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates. Sci Transl Med 11 November 2009: Vol. 1, Issue 6, p. 6ra15