Radiobio

Infections occur when foreign invaders take root in the human body. When most people think of infections, they think of bacteria and viruses. These however, are not the only invaders our body has to watch out for - fungi are also able to cause disease in humans. You all may be familiar with mild fungal infections, such as athletes foot and yeast infections. Some fungi however can cause life threatening illnesses. One fungus, Histoplasma capsulatum, is capable of causing severe respiratory infections. Dr. Anita Sil from UCSF chat about how this fungus gets into our body and how we clear it.

Presenting Radiobio’s first dispatch episode! This podcast focuses on the UC Merced Vernal Pools and Grassland Reserve featuring interviews from several scientists who do research on the reserve. Hydrologist Dr. Mark Rains, Herpetologist and conservation biologist Dr. Brad Shaffer, and fairy shrimp biologist Dr. Shannon Kiernan, and Reserve Director Monique Kolster. Discover what vernal pools are and what makes this ecosystem so special!

Autoimmune diseases occur when our immune systems start to attack our own cells, rather than foreign invaders. Unfortunately, very little is known about how these disorders arise in otherwise healthy individuals. Join us as we talk with B-cell immunologist and autoimmune clinician, Dr. Julie Zikherman, as we discuss how to control these inappropriate immune responses.

Genetics is a majorly hot topic in biology right now -- everything is genome sequencing this, gene expression that -- but how much do we really know? We know a lot about which genes are present in which organisms, and what certain genes do, but not a lot about how or why they do it. Our guest today, Dr. Rob Philips, is a researcher at CalTech who is working to understand the language of gene regulation, and the methods we can use to understand how genes work.

Whenever you're sick, your immune system springs into action, but how? T-cells are like the generals of your immune system, and they command your immune system in battle against pathogens. Dr Rothenberg from @CalTech tells us all about this process and how these cells train into the powerful generals they are on this episode of RadioBio.

Dr. Heinrich Jasper shows us new tools using Stem Cells that can help with both our longevity as well as degenerative disease. The Jasper lab is focused on regulatory mechanisms that control stress tolerance, metabolism and aging with the help of fruit flies. In particular, Dr. Jasper has been recognized for making seminal discoveries about the effects of aging on stem cell behavior, and about the role of stress in regulating stem cell function. Current projects in his lab focus on the control of tissue regeneration, metabolic homeostasis, and cell death by insulin and stress signaling pathways. Here we learn how science moves from a bench in a lab at a school into an industrial clinical setting.

Two words: Flying Lizards. How'd it happen? Evolution. Evolutionary history is complicated. It can sometimes be helpful to look at funky animals to see what their unusual traits tell us about their history. For example, Dr. Jim McGuire from the University of California Berkley, studies the evolutionary correlates of size, color, and flight in lizards.

Viruses are iconically challenging to define, but they have DNA so they evolve. In the 1980s, the Human Immunodeficiency Virus (HIV) shook the world and propelled a massive undertaking to study the evolution of drug resistance in viruses. On world aids day, December 1st, 2017, we spoke with Dr. Pleuni Pennings from San Francisco State University about how viruses adapt to treatments through time.

We may not think about it this way, but there is a whole world of colors that we can not perceive or understand that other organisms use on a daily basis, like butterflies. Did you know that even males and females from the same species see the world differently? Today on RadioBio, Dr. Adriana Briscoe discusses the evolution of color vision in Heliconius butterflies using genes, physiology, and behavior.

Have you or someone you know been affected by sleep disorders, depression, or even drug or alcohol addiction. Believe it or not this may be linked to how and when you sleep...which is actually controlled by when you eat. Dr. Joanna Chiu, Professor of Entomology at UC Davis, studies the animal circadian clock and its control on organismal physiology. Besides being indispensable for the control of daily activities, defects in circadian rhythms and clock genes have also been implicated in a wide range of human disorders. The Chiu lab's goal is to dissect the molecular network and cellular mechanisms that control the circadian oscillator in animals, and investigate how this clock interacts with the environment and metabolism to drive rhythms of physiology and behavior.

If you've ever had a pet or known someone with a pet, you probably know what a round worm is, but did you know these are nematodes? 180 years of visualizing these fascinating worms gives us insight into biodiversity, evolution, and marine ecosystems. This week Dr. Holly Bik from the University of California, Riverside guides us through an exploration of these mysterious deep sea creatures using both ancient and novel techniques.

N at work. What is N? N, or nitrogen, is one of the most abundant gases in the atmosphere and is an elemental building block of life. But we can't use N from the atmosphere, we need help nitrogen fixing bacteria and plants to acquire N in a form we can use. Dr. John Stark from Utah State explains N, how it flows through natural ecosystems, and the organisms that make it work!

How do cells interact with their physical environment? Dr. Otger Campas from the University of California, Santa Barbara joins RadioBio to discuss the physical properties of cells and how the interactions between cells and their environment shape cell and organism development.

You may have heard about the human microbiome or even the pro-biotic fad, but how much do you really know about the micro-organisms that live on and in you? Dr. Embriette Hyde from UC San Diego discusses her work with the American Gut Project on understanding the world of human microbiome. This work could lead to advances in our understanding of both the human health and human disease.

Have you ever wondered why males and females of a species are different sizes, shapes, and colors? Dr. Marie-Claire Chelini, University of California Presidential Post-doctoral Fellow, discusses her research on the evolution of sexual size dimorphism in crab spiders.

Everyone knows what hunger feels like and understands the drive to seek food when hungry, but how does it work? Dr. Zachary Knight from UCSF joins RadioBio to discuss his work on understanding the pathways in the brain that sense hunger to drive behavior. Knight's work is revealing new insights into how the brain makes decisions about food, whether it looks tasty, and how hunger dictates behavior. These results could lead to important advances in our understanding of eating disorders.

How do misfolded proteins cause human neurodegenerative diseases, like Alzheimer's, ALS, and Parkinson's? The Gitler lab at Stanford University studies the cellular biology underlying protein-misfolding diseases using the model organism yeast. Since dealing with misfolded proteins is an evolutionary problem, they hypothesize that the mechanisms employed to cope with misfoldings is likely conserved from yeast to humans. Gitler's long-term goal is to identify the critical genes and cellular pathways affected by misfolded human disease proteins.

Evolution; no small topic. Biologists can use a diverse array of systems to try to test evolutionary concepts. Some systems, like bacteria, are useful for looking at how evolution happens in real time, because they have such short generation times. Others, like animals, are much more difficult, but can allow us to ask really interesting questions like how behavior influences evolutionary processes. Dr. Kathleen Ferris, asks questions about how organisms respond to stress in an evolutionary sense using two very different systems.

How does antibiotic resistance evolve? In this week's episode, Dr. Dan Weinreich joins RadioBio to discuss gene evolution and how it can lead to antibiotic resistance!

Ever wonder where species come from? Do species even exist? Why do they matter? RadioBio discusses the speciation process through space and time with Dr. Jack Sites Jr.