Sinopsis

Mendelspod was founded in 2011 by Theral Timpson and Ayanna Monteverdi to advance life science research, connecting people and ideas. Influenced by the thinking tools developed by Eli Goldgratt, the founders bring a unique approach to media in the life sciences. With help from our advisors around the industry, Mendelspod goes beyond quick sound bites to create a space for probing conversations and deep insight into the topics and trends which shape the industry's future and therefore our future as a species.

Episodios

  • The Pros and Cons of Expanded Carrier Screening with Mary Norton, UCSF

    The Pros and Cons of Expanded Carrier Screening with Mary Norton, UCSF

    16/06/2020

    Mary Norton is a perinatologist and clinical geneticist at UCSF who says that in the age when we are diagnosing ever more rare diseases, adding to the carrier screening panel can be a good thing, but it’s complicated. But it can be a good thing. But it’s complicated.

  • Is This A Unique Time for Science? We Ask Sci-fi Writer Kim Stanley Robinson

    Is This A Unique Time for Science? We Ask Sci-fi Writer Kim Stanley Robinson

    11/06/2020

    Has this pandemic presented a unique moment for science in our history? Or is it just a strange and temporary moment of science fiction? Or both? Sci-fi author Kim Stanley Robinson (The Mars Trilogy, New York 2140 and Red Moon) recently penned an essay in the New Yorker about how the virus has “changed our imaginations” and created a new “structure of feeling.”

  • May 2020 with Nathan and Laura: Vaccine News, Notre Dame Argument, COVID Genetic Targets

    May 2020 with Nathan and Laura: Vaccine News, Notre Dame Argument, COVID Genetic Targets

    01/06/2020

    Happy summertime! We had positive news this month about an mRNA vaccine from Moderna. We also saw how during a pandemic, the process of science is especially abnormal. Nathan says let's be happy about the good news. Laura's ringing with alarm bells, sensing conflicts of interest right and left.

  • Matt Loose on Read Until or Adaptive Sequencing

    Matt Loose on "Read Until" or Adaptive Sequencing

    28/05/2020

    Back before the world turned upside down, you know, all those years ago--early this February--a paper popped up on bioRxiv called, “Nanopore adaptive sequencing for mixed samples, whole exome capture and targeted panels." It’s an interesting paper. In the paper, the authors, led by Matt Loose from the DeepSeq lab at the University of Nottingham, describe a method unique to nanopore sequencing where one can do "selective sequencing of single molecules in real time by individually reversing the voltage across specific nanopores.”

  • The Current State of Coronavirus Vaccines with Jeff Stein, Cidara Therapeutics

    The Current State of Coronavirus Vaccines with Jeff Stein, Cidara Therapeutics

    21/05/2020

    What is the key to getting a coronavirus vaccine? “Manufacturing,” says today’s guest, Jeff Stein of Cidara Therapeutics. Jeff joined us just last fall to talk about his company’s exciting new technology, an immunotherapy, that is a universal flu preventative and therapy. Yes, you read that right. A universal flu preventative.

  • April 2020 Review with Nathan and Laura: Ioannidis Scandal, Antibody Testing, Ethics Questions

    April 2020 Review with Nathan and Laura: Ioannidis Scandal, Antibody Testing, Ethics Questions

    01/05/2020

    Our commentators, Nathan Pearson of Root and Laura Hercher of Sarah Laurence College, join us to look back on month two of the first modern pandemic. We begin with a scandal that rocked the Twitter science community and talk about how science itself may be having a big moment. Will this be a silver lining for this strange year? Then it’s on to antibody testing. What would a good antibody test need to do? And will there be tough ethical questions when some “have their immunity papers” and go back to work while others do not?

  • Lab Director Speaks to the Challenges of COVID-19 Testing: Elaine Lyon, HudsonAlpha

    Lab Director Speaks to the Challenges of COVID-19 Testing: Elaine Lyon, HudsonAlpha

    14/04/2020

    Why have diagnostic tests for the Coronavirus been slow on the scene? What have been the challenges for lab directors? Were they scientific? Were they regulatory? Were they scaling challenges? Are they still scaling challenges? Supply chain problems? Elaine Lyon worked for many years at the molecular genetics lab at ARUP at the University of Utah and is now the Clinical Services Lab Director at Hudson Alpha. In both of these jobs she has designed and overseen the design of many diagnostic tests.

  • FDA in the Time of Coronavirus: Understanding the New VALID Act with Turna Ray, GenomeWeb

    FDA in the Time of Coronavirus: Understanding the New VALID Act with Turna Ray, GenomeWeb

    07/04/2020

    After the virus reached American shores, was the FDA quick enough to allow companies and labs to develop their own tests without restrictive oversight? The question sparked a sweeping new bill in congress, the VALID Act that could overhaul FDA oversight of diagnostics altogether—something that has been clamored for for a generation. Turna Ray has been covering the FDA and diagnostics for GenomeWeb since 2006. She has recently written a piece on the new VALID Act that includes responses from various members of the community.

  • March 2020 Review with Nathan  Laura: Corona Gets Personal, Where Are the Tests?, the VALID Act, Some non-Corona Science

    March 2020 Review with Nathan & Laura: Corona Gets Personal, Where Are the Tests?, the VALID Act, Some non-Corona Science

    02/04/2020

    Laura comes to us from her flat in New York, Nathan is stuck in San Diego, but they are here and ready to discuss what a month ago was a warning and now is a full blown world crisis. What have they faced personally? What are their thoughts on testing? And what are some of their early big picture reactions as to how this will all go down? We make some time for some Corona-free science as well.

  • 90% Go Undiagnosed, Says Geisinger’s Amy Sturm of FH Patients

    90% Go Undiagnosed, Says Geisinger’s Amy Sturm of FH Patients

    26/03/2020

    More than one in two hundred people have an inherited form of heart disease. But most don’t know it. Often on Mendelspod we talk about cancer genomics, but in the area of cardio, too, genetic testing can save lives. Amy Sturm is the Director of Genomic Counseling and Screening Program at Geisinger Health Systems. There she has led the effort to return the results of cardio genetic tests to over 1,000 patients.

  • Lisa Alderson on Her Telegenetics Firm, Genome Medical, Also Speaks to the DTC Downturn

    Lisa Alderson on Her Telegenetics Firm, Genome Medical, Also Speaks to the DTC Downturn

    10/03/2020

    Lisa Alderson has been helping to build genetic testing companies for a while. In 2016 she co-founded her own company, Genome Medical, a tele-genomics firm to help patients and providers understand genetic testing results. Anyone in the genetic testing industry will know that Genome Medical’s offering addresses a burning need. As Lisa remarks in today’s show, genetics is complicated.

  • February 2020 Review with Nathan and Laura: Coronavirus, Medicare for All, and Live from AGBT

    February 2020 Review with Nathan and Laura: Coronavirus, Medicare for All, and Live from AGBT

    28/02/2020

    What do we actually know about the novel coronavirus, we ask our two monthly commentators at the outset of February’s review show. Then, speaking of pandemics, as Bernie fever sweeps America, we explore the charge that Medicare for All means an end to innovation. Laura gives an update on the status of the genetic counseling bill, and Nathan comes to us live from AGBT with highlights from Marco Island.

  • Pouria Sanae on the DTC Slowdown and His New Precision Health Testing Platform

    Pouria Sanae on the DTC Slowdown and His New Precision Health Testing Platform

    13/02/2020

    “To be fully honest, I think some of these tests are scary tests. I’ve had the luxury of testing myself . . . some of this needs to have the physician and the genetic counselor involved.” That’s Pouria Sanae, a newcomer to our field via Yahoo and Helix. He’s also a Swede which gives him a fresh perspective on American genomic culture. Last month Pouria and his co-founders launched ixlayer, a new platform that integrates many of the players in the genomic medicine space: DTC companies, clinical labs, and physician/providers.

  • January 2020 Review: Genetic Counselors vs ACMG, 23andMe Layoffs, Privacy

    January 2020 Review: Genetic Counselors vs ACMG, 23andMe Layoffs, Privacy

    31/01/2020

    23andMe lays off over 100 employees. Illumina comes to the JP Morgan empty-handed. Has Precision Medicine seen it’s heyday already? Or are we gearing up for another wave of innovation? Nathan and Laura are again ready for the tough questions of genomics. We begin with the current spat between genetic counselors and the ACMG. Like, . . . huh?

  • December 2019.

    December 2019.

    27/12/2019
  • End-of-Year Special Guest: Ewan Birney on Race, UK Genomics

    End-of-Year Special Guest: Ewan Birney on Race, UK Genomics

    17/12/2019

    Our end-of-year special guest is one of the U.K.’s top genomicists, Ewan Birney, Co-Director of the European Bioinformatics Institute at EMBL. He is also the non-Executive Director for Genomics England.  Ewan's perhaps best known for his work with the ENCODE consortium.

  • November 2019 with Nathan and Laura: Happy Birthday CRISPR Babies, 23andMe for Embryo Selection, and Golden Rice, Almost

    November 2019 with Nathan and Laura: Happy Birthday CRISPR Babies, 23andMe for Embryo Selection, and Golden Rice, Almost

    02/12/2019

    The gene edited babies, Lulu and Nana, turn one. Laura Hercher says it feels like it’s been five years. Nathan says, “Happy Birthday.” Along with our genomics headline party this month, we also discuss a comment that came in from our last show which leads us to the question, can we discuss science without discussing politics? It’s Nathan, Laura and Theral for almost a full hour sifting through November’s news.

  • Learning from the Fields Mistakes, Ancestry.com Rolls out Physician Ordered Health Testing

    Learning from the Field's Mistakes, Ancestry.com Rolls out Physician Ordered Health Testing

    26/11/2019

    Just in time for Black Friday, Ancestry.com has launched new health testing. Thanksgiving week (the company calls the shopping holidays the “Turkey Five”) has been kind to what is the largest DNA testing company in the world. Back in 2017, their ancestry test competed with the Instapot for Amazon’s top sellers on the biggest shopping day of the year. To date Ancestry has sold over 15 million DNA tests.

  • The Gene Edited Babies Saga - A Year Later with Hank Greely

    The Gene Edited Babies Saga - A Year Later with Hank Greely

    22/11/2019

    On November 25th, 2018, the world was shocked to find out a Chinese scientist, He Jiankui, had edited the germline of twin girls-and the twins had been born. Many in the scientific community remember that Sunday afternoon well as the story broke on MIT's Tech Review, "EXCLUSIVE: Chinese scientists are creating CRISPR babies." Today’s guest can even tell you what he had for dinner that Sunday and just what was his reaction. "Holy Shit!"

  • Improving Quantitative Evidence for Genetic Tests: Carlos Araya, Invitae

    Improving Quantitative Evidence for Genetic Tests: Carlos Araya, Invitae

    14/11/2019

    Warning: the first part of this story can sound quite typical. Three co-founders with backgrounds in genomics and AI found a Stanford spinout. Their goal: to bring the tools of AI and computational modeling to unlock the medical secrets of the genome and deliver those to patients. They call this company, Jungla—Spanish for “jungle”—naming not only their adventure, but the whole problem. Then things get interesting.

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